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Chill the F* OUT Nasal Spray | CTFO

Chill the F* OUT Nasal Spray | CTFO 3-Month Membership Program

$1,050.00

4.9 Avg. Rating

1000+ Reviews

  • Follow-up Exam
  • Lab Review
  • Dose Adjustments
  • Certificate of Authenticity
  • 503A Pharmacies
  • 99% Pure
  • US-based Peptides
Chill the F* OUT nasal spray, often referred to as CTFO, combines two peptides, Selank and PE-22-28, that have been studied for their possible connection to the body’s stress response and sense of calm. Selank is a peptide developed based on a naturally occurring immune system compound and has a longer research history, primarily through studies conducted in Russia. PE-22-28 is a much newer and more experimental peptide that has drawn scientific interest for its potential role in mood-related pathways.
This nasal spray offers a needle-free way to take these peptides together, which some patients prefer for comfort and convenience as part of a stress-management routine.
Patients commonly ask about this combination because they are interested in supporting a calm, steady mood, especially during periods of high stress, as part of a broader wellness plan. Some patients are also curious about non-stimulant, non-habit-forming options to explore alongside healthy stress-management habits.
It’s especially important to understand that PE-22-28 is a very early-stage research compound, and this page is meant to give you an honest, clear picture of just how limited the current evidence is for that specific ingredient.
Think of your body’s stress response as a system that can either stay activated too long or settle back down once a stressful moment passes. Selank is thought to interact with pathways related to this stress response and general sense of calm, and it has a moderate research history exploring this potential role, mostly through studies conducted outside the United States. PE-22-28 works through a different, more experimental mechanism. It’s being studied by researchers as a potential way to influence certain channels in brain cells that may play a role in mood regulation. This research is still in very early, mostly animal-based stages, and much less is understood about how it works in people compared with Selank. When delivered as a nasal spray, both peptides need to pass through the lining inside the nose to reach the bloodstream, and absorption can vary from person to person. Because PE-22-28 in particular is such a new compound, there is limited information about how consistently it is absorbed through this route.
  • May help support a calm, steady mood
  • Has shown promise in research related to the body’s stress response
  • Is currently being studied for its potential role in supporting emotional balance
  • May assist with general wellness support during periods of high stress
These benefits reflect general research interest rather than confirmed outcomes, and this is especially true for PE-22-28, which has a very limited and mostly preclinical research base. Individual responses vary.
People who commonly ask their provider about this nasal spray include those interested in:
  • General stress and mood wellness support
  • Support during demanding or high-pressure periods
  • Wellness optimization as part of a broader stress-management routine
  • Longevity-focused health planning
This combination is not intended for everyone, and it is not a substitute for care related to any diagnosed anxiety or mood condition. A licensed provider can help determine whether it is a reasonable option based on your health history and goals.
Selank has been studied, primarily through research conducted in Russia, for its potential role in supporting the body’s stress response and general sense of calm. This research includes both animal studies and some smaller human studies, giving Selank a more established, though still specialized, research base compared with many newer peptides. PE-22-28 is a much newer compound, and the available research is almost entirely limited to laboratory and animal studies exploring its potential effects on mood-related brain pathways. Human clinical research on PE-22-28 specifically is very limited to essentially nonexistent in the published literature, which means most of what is discussed about this ingredient is based on early, preliminary science rather than established human outcomes. Because of this significant difference in research maturity between the two ingredients, it’s honest to say that this combination represents an evolving and, in the case of PE-22-28, quite early area of research. Individual responses vary, and your provider can help you understand the real difference between what is known about Selank and what remains largely theoretical for PE-22-28.
Possible side effects associated with this nasal spray may include nasal irritation, headache, dizziness, or temporary changes in sleep patterns. Because PE-22-28 has such a limited research history, particularly in humans, the full range of possible side effects for this specific ingredient is not well understood. This combination may not be appropriate for patients with certain neurological or psychiatric conditions, active cancer, or those who are pregnant or breastfeeding. Given the very early research stage of PE-22-28, a complete and thorough medical evaluation is especially important before considering this product. Medical supervision is important because your provider can monitor your response over time and help you make an informed decision given the current, limited state of evidence for one of the two ingredients. Following your prescribed treatment plan as directed, rather than adjusting it independently, supports both your safety and your overall experience.

What does this nasal spray do?

It is studied for its potential role in supporting a calm mood and the body’s natural stress response.

How long before I may notice changes?

Some patients report changes in mood or stress levels within days to a few weeks, though timelines vary and results are not guaranteed, especially given the limited research on PE-22-28.

Is it an injection?

No, this is administered as a nasal spray instead of an injection.

Can it be combined with other peptides?

This should only be considered under medical guidance, given the early research stage of one of the ingredients.

Can it be combined with GLP-1 medications?

Some patients use peptide therapy alongside GLP-1 medications as part of a broader wellness plan. Your provider will review your history before making recommendations.

Will I need lab work?

Your provider may review existing labs or recommend testing to help evaluate whether this therapy is appropriate for you.

Who should avoid this peptide combination?

Patients with certain neurological or psychiatric conditions, active cancer, or who are pregnant or breastfeeding are generally not appropriate candidates. Your provider will review your complete history.

How long do patients typically remain on therapy?

Length of treatment varies by individual goals, and many programs are structured around a three-month evaluation period.

Is a consultation required?

Yes, a telehealth consultation with a licensed provider is required before starting treatment.

Is PE-22-28 well studied in humans?

No, not yet. Most existing research on PE-22-28 comes from animal and laboratory studies. Your provider can help you understand what this means for your expectations.
Every peptide treatment program at SevenHealth is built to be thorough, transparent, and medically supervised. This includes:
  • An initial telehealth medical history and comprehensive evaluation with a licensed medical provider
  • Review of previous laboratory results when available, or recommendations for laboratory testing when medically appropriate
  • Personalized treatment recommendations based on your medical history and goals
  • Three months of prescribed peptide therapy when medically appropriate
  • A customized dosing and titration schedule specific to your prescribed peptide
  • A comprehensive follow-up appointment approximately three months after starting treatment
  • Review of your progress, discussion of results, treatment adjustments if medically appropriate, and continued provider guidance
  • Ongoing provider oversight throughout your treatment program
  • No additional fees for appointments included within the treatment program
  • No additional fees for laboratory review as part of your treatment
Our goal at SevenHealth is to make peptide therapy simple, transparent, and medically supervised from your first consultation through every follow-up visit.
SevenHealth focuses on individualized, provider-guided care rather than a generic treatment approach. Every plan is built around your specific health history and goals, with all prescriptions overseen by a licensed medical provider. Medications are sourced through FDA-registered 503A U.S. compounding pharmacies that follow applicable quality standards, giving patients added confidence in the products they receive. Dosing is guided by your provider throughout treatment, and a three-month follow-up appointment allows for progress review and adjustments as needed. Pricing is transparent, with no surprise appointment or lab review fees within your treatment program, so you always know what to expect from start to finish.
  • This nasal spray combines Selank, a moderately well-researched calming peptide, with PE-22-28, a much newer and more experimental compound
  • Selank has a specialized research history, primarily from studies conducted in Russia, including some human research
  • PE-22-28 research is almost entirely limited to animal and laboratory studies, with very little published human data
  • Potential benefits center on calm mood and stress support, and individual responses vary significantly given the research gap between ingredients
  • This combination is not appropriate for everyone, including patients with certain neurological or psychiatric conditions
  • A complete medical evaluation is required before starting treatment
  • SevenHealth provides ongoing provider oversight, lab review, and a three-month follow-up as part of every treatment program
  • Because PE-22-28 research is so early, expectations should be especially conservative and realistic

Educational Disclaimer

This information is provided for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Peptide therapy should only be used under the supervision of a licensed healthcare provider after an appropriate medical evaluation. Individual results may vary.

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